Qining Fu
Nationality
China
Current Position
Associate Chief Physician
Organization
The First Affiliated Hospital of Chongqing Medical University
Visceral / Miscellaneous Session

Topic: A novel bioengineered vascular graft in canine model

Abstract

Synthetic arteriovenous grafts (AVGs) continue to be an important option for hemodialysis patients. Expanded polytetrafluoroethylene (e-PTFE) is the most widely used material. However, high risk of infection and poor patency make e-PTFE more like a reluctant action. Bioengineered vascular graft, prepared using invivo tissue engineering, show potential for vascular regeneration. But their mechanical strength is typically poor. Inspired by architectural design of steel fiber reinforcement of concrete for tunnel construction, poly(-caprolactone) (PCL) fiber skeletons (PSs) were fabricated by melt-spinning and heat treatment. The PSs were subcutaneously embedded to induce the assembly of host cells and extracellular matrix to obtain PS-reinforced biotubes (PBs). Heat-treated medium fiber-angle PB (hMPB) demonstrated superior performance when evaluated by in vitro mechanical testing and following implantation in canine arteriovenous graft models. Overall, hMPB demonstrated appropriate mechanics, puncture resistance, rapid hemostasis, vascular regeneration, and long-term patency, without incidence of luminal expansion or intimal hyperplasia. These optimized hMPB properties show promise as an alternatives to e-PTFE grafts in clinical applications.

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