Invited Speakers
Makoto Samura
Current Position
.Medical staff, Division of Vascular Surgery, Yamaguchi University Graduate School of Medicine
.Visiting Instructor, Division of Vascular Surgery, Stanford University School of Medicine
Yamaguchi University Graduate School of Medicine Stanford University School of Medicine
Abdominal Aorta & Aortic iliac SessionFriday, Oct. 21, 2022 13:30-17:00 @Ballroom I

Topic: Endovascular Aneurysm Repair with Inferior Mesenteric Artery Embolization for Preventing Type II Endoleak -A Prospective Randomized Controlled Trial


Objective: This study aimed to evaluate the effect of inferior mesenteric artery (IMA) embolization during endovascular aneurysm repair (EVAR) in patients at high risk of type II endoleak (T2EL) in randomized controlled trial (RCT). Methods: Patients scheduled for elective EVAR between April 2014 and March 2018 were eligible. Patients at high risk of T2EL (IMA patency with IMA ≥3 mm, LAs ≥2 mm, or an aortoiliac-type aneurysm) were prospectively randomized to receive EVAR with or without IMA embolization. The primary endpoint was occurrence of T2EL during follow-up. Secondary endpoints included aneurysmal sac changes, adverse events from IMA embolization, and reintervention rate due to T2EL. Results: A total of 106 patients were randomized to the embolization group (group A, n = 53) or the nonembolization group (group B, n = 53). The incidence of T2EL was significantly lower in the embolization group (23.9% in group A vs. 53.8% in group B; P =0.004) during thefollow-up period (50.2 ± 21.9 months in group A and 52.9 ± 23.1 months in group B). Sac diameter changes, the incidence of aneurysmal sac growth (≥5 mm) related to T2EL, and freedom from sac enlargement (≥5 mm) related to T2EL at 5 years were −6.5 ± 8.9 mm vs. −1.1 ± 13.1 mm, 6.5% vs. 25.0%, and 97.5% vs. 72.0% in groups A and B, respectively (P = 0.025; P = 0.015; P = 0.018), which show that both shrinkage of aneurysm and freedom from sac enlargement are significantly higher in group A. Conclusions: Our results demonstrated the effectiveness of IMA embolization during EVAR in high-risk patients for the prevention of T2EL, which is suggested for avoiding aneurysmal sac enlargement related to T2EL.





・2008 M.D., Yamaguchi University Graduate School of Medicine
・2016 Ph.D. (Dr. of Medical Science), Yamaguchi University, Department of Surgery and Clinical Science

Research Experience

・2016 – 2017 Cell based neovascularizaion combined with apelin for critical limb ischemia
・2018 – 2019 Neovascularization via increase of intrinsic apelin by ischemic preconditioning


・2013 Best oral presentation award (The 8th Korea-Japan Joint Meeting of Vascular Surgery)
・2020 Research Fellowship (The Uehara Memorial Foundation, Japan)

Selected Publications
  • Samura M, et al. Endovascular Aneurysm Repair With Inferior Mesenteric Artery Embolization for Preventing Type II Endoleak: A Prospective Randomized Controlled Trial. Ann Surg. 2020;271:238-244.
  • Samura M, et al. Recurrent Delayed Periaortitis after Endovascular Aneurysm Repair. J Vasc Interv Radiol. 2019: pii: S1051-0443(18)31495-7.
  • Samura M, et al. Therapeutic strategies for cell-based neovascularization in critical limb ischemia. J Transl Med. 2017;15:49.
  • Samura M, et al. Combinatorial Treatment with Apelin-13 Enhances the Therapeutic Efficacy of a Preconditioned Cell-Based Therapy for Peripheral Ischemia. Sci Rep. 2016;6:19379.
  • Samura M, et al. Chimney technique for aortic dissection involving an aberrant right subclavian artery. Ann Thorac Surg. 2014;97:315-7.

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